News from the NNI Community - Research Advances Funded by Agencies Participating in the NNI

Aortic aneurysms are bulges in the aorta, the largest blood vessel that carries oxygen-rich blood from the heart to the rest of the body. "The soft tissues that make up blood vessels act essentially like rubber bands, and it's the elastic fibers within these tissues that allow them to stretch and snap back," said Prof. Anand Ramamurthi, from Lehigh University. Ramamurthi and colleagues are working on minimally invasive ways to regenerate and repair these elastic fibers using nanoparticles designed to release novel regenerative therapeutics. The innovative techniques could enable treatment soon after an aneurysm is detected and potentially slow, reverse, or even stop its growth.

Researchers from the University of Cincinnati and Texas A&M University have demonstrated a new chemical process that grafts nanotubes to copper, aluminum, gold, and other metal surfaces to create a strong, consistent, conductive link. Through computational calculations, the researchers have shown that carbon atoms in the link actually bond with two copper atoms, creating an especially strong bond.

Researchers from North Carolina State University, Arizona State University, Jeonbuk National University in South Korea, and Sungkyunkwan University in South Korea have discovered that liquid metal composites can spontaneously grow over four times in volume when exposed to water, while retaining metallic conductivity similar to their starting material. This growth occurs because water infiltration promotes oxidation reactions that generate porous gallium oxyhydroxide while freeing hydrogen gas. This gradually accumulating gas exerts internal pressure that expands the liquid metal composite further – much like bread dough rising from the byproducts of yeast fermentation.

Researchers at the University of Pennsylvania and Case Western Reserve University have developed an in situ method for rapid and efficient synthesis of degradable branched lipidoids, key components of lipid nanoparticles, which are used for delivery of messenger RNA (mRNA) vaccines. The new method simplifies the manufacture of lipid nanoparticles and improves their ability to deliver mRNA to cells. The team tested the method for the treatment of obesity and genetic diseases. 

A team of researchers from Vanderbilt University, Northwestern University, and the University of Rhode Island has developed a novel method for producing nanoparticles of diverse morphologies that can act as nanocarriers for delivering therapeutics to cells. The researchers used these nanocarriers to deliver a molecule that can boost the immune system to fight viral infections and a molecule that can slow melanoma tumor growth. The novel method is industrially scalable, and the diverse shapes and sizes of nanocarriers that can be produced may allow the delivery of distinct biomolecular cargos for therapeutic applications addressing a variety of diseases.

Researchers at the Massachusetts Institute of Technology (MIT), using facilities at MIT and Harvard University’s Center for Nanoscale Systems (part of the National Nanotechnology Coordinated Infrastructure network), have demonstrated current-controlled, non-volatile magnetization switching in an atomically thin van der Waals magnetic material at room temperature. Magnets composed of atomically thin van der Waals materials can typically only be controlled at extremely cold temperatures, so the fact that the researchers were able to control these materials at room temperature is key. The researchers’ ultimate goal is to bring van der Waals magnets to commercial applications, including magnetic-based devices with unprecedented speed, efficiency, and scalability. 

Physicists from the Massachusetts Institute of Technology have found that when five sheets of graphene are stacked like steps on a staircase, the resulting structure provides the right conditions for electrons to pass through as fractions of their total charge, with no need for any external magnetic field. The results are the first evidence of the "fractional quantum anomalous Hall effect" (the term "anomalous" refers to the absence of a magnetic field) in crystalline graphene, a material that physicists did not expect to exhibit this effect.

An international team of researchers from Princeton University, the University of Texas at Dallas, the National High Magnetic Field Laboratory in Tallahassee, FL, the Beijing Institute of Technology, and the University of Zurich in Switzerland has observed long-range quantum coherence effects in a topological insulator-based device, which may enable the development of efficient topological electronic devices. "Unlike conventional electronic devices, topological circuits are robust against defects and impurities, making them far less prone to energy dissipation, which is advantageous for greener applications," said M. Zahid Hasan, one of the scientists involved in this study. This work builds on 15 years of research at Princeton University on the development of quantum devices using bismuth bromide topological insulators – only a few nanometers thick and capable of maintaining quantum coherence at room temperature.

Researchers led by Northwestern University and the University of Wisconsin-Madison have introduced a pioneering approach aimed at combating neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The study focused on disrupting a type of protein-protein interaction that plays a role in the body's antioxidant response. The research holds promise for mitigating the cellular damage that underlies neurodegenerative diseases.

Researchers from Harvard University and Utrecht University in The Netherlands have developed a previously elusive way to improve the selectivity of catalytic reactions, adding a new method of increasing the efficacy of catalysts for a potentially wide range of applications in various industries, including pharmaceuticals and cosmetics. Inspired by the structure of butterfly wings, the researchers designed a new catalyst platform that partially embeds nanoparticles into the substrate, trapping them so they don't move around during catalysis, while leaving the rest of the nanoparticles' surfaces exposed, enabling them to perform the catalytic reactions efficiently and without agglomeration.